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Safety & Toxicity |
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No significant side effects information
is available so far. According to Ayurveda herbs
can be taken in combination with other herbs to
neutralize the intoxicity of one herb with the opposing
effect of the other or to enhance the particular
effect of one herb with the help of other. |
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Standardization |
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Cur-500 powder extract is standardized
to total cuircuminoids NLT 95% ( By spectrophotometeric
method). |
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Anticancer properties of Cur-500 |
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:: Cur-500 inhibits tumorigenesis |
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:: Cur-500 exhibits antiproliferative
against cancer cell |
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:: Cur-500 downregulates the activity
of EGFR and expression of HER2/neu |
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:: Cur-500 downregulates the activation
of Nuclear Factor-KB. |
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:: Cur-500 downregulates the activation
of AP-1 and c-jun Kinase |
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:: Cur-500 suppresses the induction
of adhesion molecules |
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:: Cur-500 downregulates COX-2 expression |
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:: Cur-500 inhibits angiogenesis: |
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:: Cur-500 suppresses the expression
of matrix metalloprotease (MMP)-9 and inducible
nitric oxide oxidase (iNOS). |
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:: Cur-500 downregulates cyclin DI
expression |
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Effect of Cur-500 on atheroscler
and myocardial infarction. |
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:: Cur-500 inhabits the proliferation
of vascular smooth muscle cells. |
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:: Cur-500 lowers serum cholesterol
levels |
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:: Cur-500 inhibits LDL oxidation. |
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:: Cur-500 inhibits platelet aggregation. |
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:: Cur-500 inhibits myocardial infarction. |
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Cur-500 suppresses diabetes |
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Cur-500 stimulates muscle regeneration |
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Cur-500 enhances wound-dealing. |
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Cur-500 suppresses symptoms associated
with arthritis. |
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Cur-500 reduces the incidence
of cholesterol gall-stones (CGS) formation |
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Cur-500 modulates multiple sclerosis |
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Cur-500 blocks the replication
of HIV |
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Cur-500 affects Alzheimer's disease |
|
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Cur-500 protects against cataract
formation in lenses |
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Cur-500 protects from drug-induced
myocardial toxicity |
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Cur-500 protects from drug-induced
lung injury |
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Cur-500 protects from drug-induced
nephrotoxicity |
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Cur-500 helps in stopping the
spread of breast cancer, tumor cells to the lungs |
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Dosage |
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Healthy people should take one capsule,
once or twice daily with meals.Or as directed by
the physician. |
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Caution |
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Always take with meals because curcumin
can cause gastric irritation and ulceration , if
taken on empty stomach. |
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Clinical Trail |
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A clinical trail with Turmeric was
conducted in 114 patients of respiratory diseases
consisting 71 cases of bronchitis, 13 cases of bronchiectasis,
18 cases of bronchial asthma and 12 cases of tropical
eosinophilia. Drug was administered in gradually
increasing doses from 4 to 32 gm daily for a period
of 15 to 45 days. Significant improvement in signs
and relief in airway resistance was observed in
11 cases of bronchitis, 1 case of bronchiectasis,
5 cases of bronchial asthma and 6 cases of tropical
eosinophilia. |
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References |
| |
Ammon HP, wahi MA. Pharmacology of Curcuma longa.
planta Med 1991;57:1-7 |
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Cheng
AL, hsu CJl, LIn JK, et al. Phase I clinical trial
of curcumin, a chemopreventive
agent, in patients with high-risk
or pre-malignant lesions. Anticancer Res 2001; 21
:
2895-2900. |
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Clinical
development plan: curcumin. J cell Biochem Suppl
1996; 26:72-85 |
| |
Huang
MT, wang ZY, Georgiadis CA, Laskin JD, Conny AH,
Inhibitory effects of curcumin
on tumor initiation by benzo[a]pyrene
and 7,12 dimethylbenz[a]anthracene-induced.
Carcinogenesis 1992;13:2183-2186. |
| |
Han
SS, Chung ST, Robertson DA, Ranjan D, Bondada S.
lymphoma by downregulation
of egr-l, c-myc, bel-XL, NF-kappa
B, and p53. Clin lmmunol 1999; 93:152-161 |
| |
Ramachandran
C, You w. Differential sensitivity of human mammary
epithelial and
breast carcinoma cell lines to
curcumin. Breast Cancer Res Treat 1999; 54:269-278. |
| |
Conney
AH, Lysz T, Ferraro T, et al. Inhibitory effect
of curcumin and some related
dietary compunds on tumor promotion
and arachidonic acid metabolism in mouse skin.
Adv Enzyme Regul 1991; 31:385-396. |
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Rao
CV, Rivenson A, Simi B, Reddy BS. Chemoprevention
of colon carcinogenesis by
dietary curcumin, a naturally occurring
plant phenolic compound. Cancer Res 1995;
55:259-266. |
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NOTE:
These statements have not been evaluated by the
Food and Drug Administration, This product is not
intended to diagnose treat, cure or prevent any
disease. |
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